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The placebo effect can be good medicine, for pain and other problems

Catarina Craveiro, a biomedical research technician from Lisbon, had been hobbled by lower back pain from scoliosis since childhood, unable to do much physically and dependent on ibuprofen for relief.

“It really interfered with my life,” she says. “I had bad pain. I wanted to do the same things as my friends, and I was not able to.”

In 2013, she signed up for a clinical trial, “expecting they had some magical drug that would take my pain away,” and was disappointed — and skeptical — to learn that the research would be studying the effects of a medically inert placebo, which looks like a real drug, and is taken like one, but lacks active ingredients. “I didn’t believe it was going to work but gave it a try,” she recalls. “It couldn’t be any worse than my actual situation at that point.”

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